Learning And MemoryFirst evidence of a delay-dependent working memory-enhancing effect of modafinil in miceBéracochéa, DanielCA; Cagnard, Barbara; Célérier, Aurélie; le Merrer, Julie; Pérès, Michel1; Piérard, Christophe1Author Information Laboratoire de Neurosciences Cognitives, Université de Bordeaux 1, UMR CNRS 5601, Avenue des Facultés, 33405 Talence Cedex; 1Institut de Medecine Aérospatiale du Service de Santé des Armées, Brétigny-sur-Orge Cedex, France CACorresponding Author Received 3 October 2000; accepted 23 November 2000 Neuroreport: February 12, 2001 - Volume 12 - Issue 2 - p 375-378 Buy Abstract This study investigated the effects of pretest injection of modafinil on delayed spontaneous alternation rates (SA) used to evaluate working memory in C57 Bl/6 mice. In a first experiment, systemic modafinil at 64 mg/kg, but not at 8 mg/kg or 32 mg/kg doses produced a significant increase of alternation scores (intertrial interval (ITI) 60 s) when compared with controls. In a second experiment, modafinil (64 mg/kg) en- hanced the alternation rates mainly at long (60 s and 180 s) but not at short (5 s) ITIs. Exploratory latencies and activity in a four hole-board apparatus were not modified by modafinil administration. These experiments are the first to demonstrate a delay-dependent working memory-enhancing effect of modafinil. © 2001 Lippincott Williams & Wilkins, Inc.