Disrupted neural responses to phonological and orthographic processing in dyslexic children: an fMRI studyTemple, Elise1, CA; Poldrack, Russell A.2; Salidis, Joanna2; Deutsch, Gayle K.3; Tallal, Paula3,4; Merzenich, Michael M.3,5; Gabrieli, John D. E.1,2Neuroreport: February 12th, 2001 - Volume 12 - Issue 2 - p 299-307 Brain Imaging Abstract Author InformationAuthors Developmental dyslexia, characterized by difficulty in reading, has been associated with phonological and orthographic processing deficits. fMRI was performed on dyslexic and normal-reading children (8–12 years old) during phonological and orthographic tasks of rhyming and matching visually presented letter pairs. During letter rhyming, both normal and dyslexic reading children had activity in left frontal brain regions, whereas only normal-reading children had activity in left temporo-parietal cortex. During letter matching, normal-reading children showed activity throughout extrastriate cortex, especially in occipito-parietal regions, whereas dyslexic children had little activity in extrastriate cortex during this task. These results indicate dyslexia may be characterized in childhood by disruptions in the neural bases of both phonological and orthographic processes important for reading. 1Institute of Neuroscience and 2Department of Psychology, 455 Serra St, Jordan Hall, Building 420, Stanford University, Stanford, CA 94305; 3Scientific Learning Corporation, Berkeley, CA; 4Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ; 5Keck Center Integrative Neuroscience, UCSF, San Francisco, CA, USA CACorresponding Author Received 5 September 2000; accepted 22 November 2000 © 2001 Lippincott Williams & Wilkins, Inc.