CLINICAL NEUROSCIENCE AND NEUROPATHOLOGYConcussions in athletes produce brain dysfunction as revealed by event-related potentialsDupuis, François1; Johnston, Karen M.2; Lavoie, Marc1; Lepore, Franco1; Lassonde, Maryse1,3Author Information 1Université de Montréal, Groupe de Recherche en Neuropsychologie Expérimentale and Institut Universitaire de Gériatrie, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, Que. H3C 3J7 2McGill University, Department of Neurosurgery, 1650 Cedar Avenue, Montrél, Que. H3G 1A4, Canada 3Corresponding Author: Maryse Lassonde Acknowledgements: This work was supported by grants from the Société de I'Assurance Automobile du Québec (SAAQ). the REPAR network from the Fonds de la Recherche en Santé du QUébec (FRSQ) and the American College of Surgeons (K.M.J.). We wish to thank Dr Sid Segalowitz and Dr Alvaro Pascual-Leone for their helpful comments on the text. Received 12 September 2000; accepted 20 October 2000 NeuroReport: December 18, 2000 - Volume 11 - Issue 18 - p 4087-4092 Buy Abstract We have used event-related potentials (ERP) to assess cerebral activity following mild traumatic brain injuries in 20 college athletes practising contact sports. Concussion victims showed a striking decrease in P300 amplitude, an effect presumed to reflect alterations in attentional-cognitive processes. Moreover, the degree of impairment was strongly related to the severity of post-concussion symptoms. Our data suggest that concussions cause objectively measurable changes in the electro-physiological markers of brain activity and hence in the functions of the structures from which they originate. ERPs may thus constitute a reliable method to accurately monitor the clinical course and recovery of head injuries in athletes. © 2000 Lippincott Williams & Wilkins, Inc.