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C×36 is dynamically expressed during early development of mouse brain and nervous system

Gulisano, Massimo2; Parenti, Rosalba2; Spinella, Francesca1; Cicirata, Federico1,3


Connexins are structural proteins that are part of the gap junctional channels which couple cells in different tissues. Connexin36 (C×36) is a new member of the connexin gene family, found to be expressed essentially if not exclusively in neuronal cells in adult CNS of mouse, rat and man. Here we have studied C×36 expression during murine embryonic development. C×36 shows a highly dynamic pattern of expression. It is first (E9.5) evident in the forebrain and later its expression expand caudally in the midbrain. At E12.5 its expression correlates with major morphogenetic boundaries in the developing mouse brain, specifically with the dorsoventral telencephalic boundary and the Zona Limitans Intrathalamica. Starting at midgestation (E12.5), it is also expressed in both sympathetic and spinal ganglia, and in two longitudinal stripes along the spinal cord.

1Dipartimento di Scienze Fisiologiche, Università di Catania, Viale A. Doria 6, 95125, Catania, Italy

3Corresponding Author: Federico Cicirata, M. G. and R. P. contributed equally to this work.

Acknowledgements: We wish to thank Vincenzo Nigro for the gift of blastula total RNA. This work was supported by CNR Grant Nr 98.02996.CT04, Italian Theleton Grant Nr D77 and EU BIOTECH2 Grant Nr BIO4-CT98-45.

Received 22 August 2000; accepted 15 September 2000

© 2000 Lippincott Williams & Wilkins, Inc.