NEUROPHYSIOLOGY, BASIC AND CLINICALIpsilateral and contralateral subthalamic activity after unilateral dopaminergic lesionPérier, C1,3; Agid, Y1; Hirsch, E C.1; Féger, J1,2 Author Information 1INSERM U289, Hôpital de La Salpêtriêre, 47 Blvd de l'Hôpital, 75651 Paris cedex 13 2Faculté de Pharmacie, Université R. Descartes, France 3Corresponding Author: C. Périer Received 4 July 2000, accepted 31 July 2000 Acknowledgements: C.P. is supported by a fellowship from the Ministére de l'Education Nationale et de la Recherche. This work was supported by grants from INSERM and National Parkinson's disease (Miami). NeuroReport: September 28, 2000 - Volume 11 - Issue 14 - p 3275-3278 Buy Abstract Unilateral lesions of the dopaminergic nigral neurons in rats are currently used as a model of Parkinson's disease. However, several neurochemical studies have questioned the possible influence of the lesioned side on the contralateral non-lesioned side. To address this question, electrophysiological recordings in the ipsilateral and contralateral subthalamic nucleus was performed on anaesthetized rats, 3, 7 and 14 days after induction of a unilateral dopaminergic lesion. At these three times, the mean discharge rate of the subthalamic neurons recorded ipsilateral to the lesion was increased by 85, 176 and 127%, respectively, whereas this rate was decreased by 16, 27 and 43%, respectively, in the opposite subthalamic nucleus. This result emphasizes the importance of interhemispheric regulation of this structure, contrasting with the unilateralized current model of the functional organization of the basal ganglia. © 2000 Lippincott Williams & Wilkins, Inc.