MOLECULAR NEUROSCIENCEDifferential somato-dendritic localization of TrkA, TrkB, TrkC and p75 mRNAs in vivoTongiorgi, E1,2,3; Armellin, M1; Cattaneo, A2 Author Information 1BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Via L. Giorgieri 10, 34127 Trieste, Italy 2International School for Advanced Studies (SISSA), 34014 Trieste, Italy 3Corresponding Author: E. Tongiorgi, [email protected] Received 12 July 2000, accepted 25 July 2000 Acknowledgements: The study was supported by the Telethon Foundation Italy (N.E0954 to E.T.) and by a joint grant from MURST and SISSA (Cofinanziamento '97 to A.C.). M.A. was recipient of a Telethon Foundation fellowship. The authors thank Drs Y. Bozzi, M. Chao and R. Klein for kindly providing the cDNAs for the different neurotrophin receptors. NeuroReport: September 28, 2000 - Volume 11 - Issue 14 - p 3265-3268 Buy Abstract TrkB mRNA was shown to be localized in the somatodendritic compartment in vitro but no data are currently available on the subcellular distribution of the neurotrophin receptors mRNAs in vivo. Here we describe the subcellular distribution of TrkA, TrkB, TrkC and p75 mRNAs in the adult rat basal forebrain. We find that TrkA, TrkC and p75 mRNAs are restricted to the cell soma but in addition, p75 mRNA labelling extends in average for 8 μm within the proximal dendrites of 34% of the labelled neurons. TrkB mRNA has a somatodendritic distribution in 95% of the labelled neurons reaching variable distances in different neurons (23–84.5 μm) and forebrain regions (mean: 40, 51 and 55 μm for diagonal band, septum and ventral pallidum). © 2000 Lippincott Williams & Wilkins, Inc.