VISION, CENTRALQuantitative aspects of the state-dependent co-variation of cat lateral geniculate and perigeniculate visual activityFunke, Klaus1,2; Eysel, Ulf T.1Author Information 1Institute of Physiology, Department of Neurophysiology, MA 3/151, Ruhr-University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany 2Corresponding Author: Klaus Funke Acknowledgements: The authors acknowledge the technical support by V. Onasch and B. Bendmann in the laboratory. We are further grateful to K. Suder and F. Wörgötter for fruitful discussions. This study has been supported by the Deutsche Forschungsgemeinschaft (SFB 509, TP A2). Received 17 January 2000; accepted 25 January 2000 NeuroReport: April 7, 2000 - Volume 11 - Issue 5 - p 1031-1037 Buy Abstract The quantitative relationship between EEG-related changes in the visual activity of perigeniculate (PGN) and lateral geniculate (LGN) neurons with overlapping receptive (r)elds was analyzed in the anesthetized and paralyzed cat. While transient response peaks were independent of the EEG state, we found opposite changes in spontaneous activity and tonic visual responses, with PGN cells increasing and LGN cells decreasing their spontaneous/tonic activity with increasing EEG delta activity in most cases. The tonic (r)ring rates of PGN and LGN cell pairs were clearly correlated with a slope of about −0.5. Thus, LGN (r)ring was low when PGN activity was high and vice versa. With a change from low to high EEG delta activity the difference between the tonic responses of PGN and LGN cells increased on average by 50 spikes/s, both for the whole population and at the single cell level, indicating that state-dependent changes in retino-geniculate transmission are regulated by a distinct ratio of PGN-LGN activity. © 2000 Lippincott Williams & Wilkins, Inc.