LEARNING AND MEMORYOlfactory based spatial learning in neonatal mice and its dependence on CaMKIIWiedenmayer, Christoph P.1,4; Myers, Michael M.1; Mayford, Mark2; Barr, Gordon A.1,3Author Information 1Department of Psychiatry, Columbia University, and of Developmental Psychobiology, New York State Psychiatric Institute, 1051 Riverside Drive Unit 40, New York, NY 10032 2Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093 3Department of Psychology, Hunter College, CUNY, New York, NY 10021, USA 4Corresponding Author: Christoph P. Wiedenmayer Acknowledgments: We thank M. Mendelsohn, R. Pennetta, 0. Yarygina and R. Bejar. This work was supported by a PIRSG from NYSPI and by NIH. Received 24 November 1999; accepted 27 January 2000 NeuroReport: April 7, 2000 - Volume 11 - Issue 5 - p 1051-1055 Buy Abstract Spatial learning and memory involves the ability to encode geometric relationships between perceived cues and depends critically on the hippocampus. Visually guided spatial learning has been demonstrated in adult animals. As infant animals rely heavily on olfaction, olfactory based spatial learning was assessed in infant mice. When 12-day-old pups were displaced from their nest, they learned within a few training trials to use the spatial pattern of odor cues to move back to the nest. However, mouse pups that over-expressed Ca2+ /calmodulin-dependent protein kinase (CaMKII) in hippocampal neurons were impaired in olfactory based spatial learning. © 2000 Lippincott Williams & Wilkins, Inc.