SOMATOSENSORY SYSTEMS, PAINInteractions of inflammatory mediators and low pH not influenced by capsazepine in rat cutaneous nociceptorsHabelt, C1; Kessler, F1; Distler, C1; Kress, M1; Reeh, P W.1,2Author Information 1Institute of Physiology and Experimental Pathophysiology, Universitätsstr. 17, D-91054 Erlangen, Germany 2Corresponding Author: P. W. Reeh Acknowledgements: This work was supported by the Deutsche Forschungsgemeinschaft (SFB 353, A 10 and B 12). Received 6 January 2000; accepted 21 January 2000 NeuroReport: April 7, 2000 - Volume 11 - Issue 5 - p 973-976 Buy Abstract The rat skin-saphenous nerve preparation was used to record from mechano-heat sensitive C-fibers whose receptive fields were superfused with various solutions of low pH and of bradykinin, serotonin and prostaglandin E2. Only synchronous application of protons and mediators resulted in a significant nearly three-fold augmentation of the nociceptive pH response, and capsazepine (10-5 M) did not block this short-lived enhancement. Thus, it does not seem to involve the capsaicin receptor (VRI) which is in contrast to a previous finding from cultured sensory neurons. © 2000 Lippincott Williams & Wilkins, Inc.