BRAIN IMAGINGHyperoxia-enhanced activation-induced hemodynamic response in human VI An fMRI studyKashikura, Kenichi1,3; Kershaw, Jeff1; Kashikura, Akemi2; Matsuura, Tetsuya1; Kanno, Iwao2Author Information 1Akita Laboratory, Japan Science and Technology Corporation (JST), 6-10 Senshu-kubota cho, Akita, 010-0874 2Department of Radiology, Akita Research Institute of Brain and Blood Vessels, 6-10 Senshu-kubota cho, Akita, 010-0874, Japan 3Corresponding Author: Kenichi Kashikura Received 2 November 1999; accepted 15 January 2000 NeuroReport: April 7, 2000 - Volume 11 - Issue 5 - p 903-906 Buy Abstract The effect hyperoxia had on the hemodynamic response to visual stimulation (black and white checkerboard alternating at a frequency of 8 Hz) of human VI was investigated using a blood oxygenation level-dependent (BOLD) contrast with an fMRI technique. Data were acquired with a 5 on/5 off block paradigm using single-shot gradient-echo echo-planar imaging. Using a two-tailed paired t-test (p < 0.05, n = 13) it was found that the mean percentage signal change and the mean number of activated pixels was significantly increased for hyperoxia (5.7 ± 0.9, 187 ± 73, mean ± SD) relative to those for normoxia (5.4 ± 0.9, 168 ± 58). We believe that these results indicate that hyperoxia enhances the activation-induced hemodynamic response in human VI. © 2000 Lippincott Williams & Wilkins, Inc.