NEUROCHEMISTRYAxonal transport of TREK and TRAAK potassium channels in rat sciatic nervesBearzatto, Bertrand1; Lesage, Florian2; Reyes, Roberto2; Lazdunski, Michel2; Laduron, Pierre M.1,3Author Information 1Laboratory of Neurophysiology, Université Libre de Bruxelles, 808 Route de Lennik CP 601, B-1070 Brussels, Belgium 2Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France 3Corresponding Authors: Pierre M. Laduron Acknowledgements: The authors thank J.J. Vanderhaegen and S.N. Schiffmann for encouragement and support in the course of the present work and J.L. Conreur for is expert assistance. B.B. is the recipient of a grant from Elf Aquitaine France and this work was supported by the Queen Elisabeth Medical Foundation. Received 7 Decemebr 1999; accepted 19 January 2000 NeuroReport: April 7, 2000 - Volume 11 - Issue 5 - p 927-930 Buy Abstract The recent cloning, functional expression and brain localization of two new potassium channels, TREK and TRAAK, led us to examine whether both channels are present in peripheral nerves and can move along axons by means of axonal transport mechanisms. Using specific antibodies directed against TREK and TRAAK peptides, we found that immunoreactivity for both potassium channels accumulates above and below a ligature in rat sciatic nerves. The process was rapid and bidirectional suggesting that the channels are associated with vesicles. This represents the first report on the axonal transport of potassium channels. © 2000 Lippincott Williams & Wilkins, Inc.