LEARNING AND MEMORY7-Nitroindazole blocks nicotine-induced conditioned place preference but not LiCl-induced conditioned place aversionMartin, Julio L.1; Itzhak, Yossef1,2Author Information 1Department of Psychiatry and Behavioral Sciences (R-629), 1011 NW 15th Street, Gautier Building Room 531, University of Miami School of Medicine, Miami, FL 33101, USA 2Corresponding Author: Yossef Itzhak Acknowledgments: This work was supported by USPHS award DA08584 from the national Institute on Drug Abuse National Institute of Health to Y.I. Received 22 December 1999; accepted 19 January 2000 NeuroReport: April 7, 2000 - Volume 11 - Issue 5 - p 947-949 Buy Abstract We have shown previously that the neuronal nitric oxide synthase (nNOS) is involved in the rewarding effect of cocaine as determined by the conditioned place preference (CPP) paradigm. In the present study we investigated the effect of the nNOS inhibitor 7-nitroindazole (7-NI) on nicotine-induced CPP and LiCl-induced conditioned place aversion (CPA) in Swiss Webster mice. Mice treated with nicotine (0.5 mg/kg) or saline every other day for 8 days (four drug and four saline sessions) developed CPP that was completely blocked by pretreatment with 7-NI (25 mg/kg). Mice treated with LiCl (150 mg/kg) developed marked aversion to the LiCl-paired compartment. LiCl-induced CPA was not affected by the pretreatment with 7-NI. These findings suggest that nitric oxide (NO) plays a role in the acquisition of reward but not of aversion and that the blockade of nicotine-induced CPP is probably not due to impairment of learning and memory. © 2000 Lippincott Williams & Wilkins, Inc.