AUDITORY AND VESTIBULAR SYSTEMSPlastic changes in the auditory cortex induced by intensive frequency discrimination trainingMenning, Hans1; Roberts, Larry E.2; Pantev, Christo1,3 Author Information 1Biomagnetism Center, Institute of Experimental Audiology, Kardinal-von-Galen-Ring 10, D-48129 Münster, Germany 2Department of Psychology, McMaster University, Hamilton, Ontario, Canada L8S 4K1. 3Corresponding Author: Christo Pantev Acknowledgements: Supported by grants from the Deutsche Forschungsgemeinschaft (Pa 392/6-2) and the Medical Research Council of Canada (MT-14033, L.E.R.). We thank R. Näätänen for helpful comments, A. Wollbrink for engineering, M. Schulz and K. Berning for technical assistance. Received 24 November 1999; accepted 7 January 2000 NeuroReport: March 20, 2000 - Volume 11 - Issue 4 - p 817-822 Buy Abstract The slow auditory evoked (wave Nlm) and mismatch field (MMF) elicited by sequences of pure tones of 1000 Hz and deviant tones of 1050, 1010 and 1005 Hz were measured before, during and 3 weeks after subjects were trained at frequency discrimination for 15 sessions (over 3 weeks) using an odd-ball procedure. The task of the subject was to detect deviants differing by progressively smaller frequency shifts from the standard stimulus. Frequency discrimination improved rapidly in the first week and was followed by small but constant improvements thereafter. Nlm and MMF responses to the deviant stimuli increased in amplitude during training. This enhancement persisted until training was finished, but decreased 3 weeks later. The results suggest a plastic reorganization of the cortical representation for the trained frequencies. © 2000 Lippincott Williams & Wilkins, Inc.