BRAIN IMAGINGFunctional brain imaging of tinnitus-like perception induced by aversive auditory stimuliMirz, Frank1,2,3,4; Gjedde, Albert2; Sdkilde-Jrgensen, Hans3; Pedersen, Christian Brahe1 Author Information 1Department of Otorhinolaryngology, Nørrebrogade 44, 8200 Aarhus C, Denmark 2PET-Centre, Nørrebrogade 44, 8200 Aarhus C, Denmark 3MR-Research Centre Aarhus University Hospitals, Nrrebrogade 44, 8200 Aarhus C, Denmark 4Corresponding Author and Address: Frank Mirz, Department of Otorhinolaryngology, Nrrebrogade 44, 8200 Aarhus C, Denmark Acknowledgements: We thank the experimental subjects for their patience and efforts. This study was supported by grants from Landsforening for Bedre Hrelse. Mnire-Tinnitus-Forening and MRC Denmark. Received 10 November 1999; accepted 10 December 1999 NeuroReport: February 28, 2000 - Volume 11 - Issue 3 - p 633-637 Buy Abstract Tinnitus is an aversive auditory percept of unknown origin. We tested the speculation that tinnitus may share neuronal processing mechanisms with aversive auditory percepts of known origin. This study revealed the functional neuroanatomy of the perception of aversive auditory stimuli. The stimuli were presented to 12 healthy volunteers so as to mimic the psychoacoustical features of tinnitus and its affective response in tinnitus sufferers. The regional cerebral blood flow distribution was measured by PET during four auditory processing conditions and one control condition. The aversive auditory stimuli activated primary and secondary auditory areas bilaterally, dorsolateral prefrontal attention areas, and structures in the limbic system which subserve emotional processing. Based on these results and findings from other functional neuroimages of tinnitus, we hypothesize that the perception of tinnitus may involve the functional linkage of these brain areas: secondary auditory cortex, dorsolateral prefrontal cortex, and limbic system. © 2000 Lippincott Williams & Wilkins, Inc.