SYNAPTIC TRANSMISSIONQuinolinic acid inhibits glutamate uptake into synaptic vesicles from rat brainTavares, Rejane G.1; Tasca, Carla I.2; Santos, Candice E. S.1; Wajner, Moacir1; Souza, Diogo O.1; Dutra-Filho, Carlos S.1,3Author Information 1Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 (Anexo) 90035-003, Porto Alegre, RS 2Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil 3Corresponding Author: Carlos S. Dutra-Filho Received 6 October 1999; accepted 7 November 1999 Acknowledgements: This study was supported by grants from the Brazilian National Research Council (CNPq), the Financing Agency for Studies and Projects (FINEP), and Pronex (41960904 and 76971025). NeuroReport: February 7, 2000 - Volume 11 - Issue 2 - p 249-254 Buy Abstract Quinolinic acid (QA) is an endogenous and potent neurotoxin associated with the neurotoxicity of various common diseases. The uptake of neurotransmitters into synaptic vesicles is an important event involved in the storage and release of neurotransmitters by vesicles. The influence of QA on the uptake of glutamate, GABA and glycine into rat brain synaptic vesicles was investigated. QA (0.3-10 mM) significantly inhibited (>50%) the uptake of glutamate into synaptic vesicles, whereas QA at concentrations up to 10 mM had no significant effect on GABA or glycine uptake. Such results indicate that QA is able to selectively inhibit the vesicular uptake of glutamate, without interfering with the uptake of the inhibitory neurotransmitters GABA and glycine. These findings might be related to the neurotoxic effects of QA in the brain. © 2000 Lippincott Williams & Wilkins, Inc.