LEARNING AND MEMORYPreserved olfactory short-term memory after combined cholinergic and serotonergic lesions using 192 IgG-saporin and 5,7- dihydroxytryptamine in ratsWirth, Sylvia1; Lehmann, Olivia1; Bertrand, Fabrice1; Lazarus, Christine1; Jeltsch, Hélène1; Cassel, Jean-Christophe1,2Author Information 1LN2C, UMR 7521 Université Louis Pasteur/CNRS, 12 rue Goethe, F-67000 Strasbourg, France 2Corresponding author: Jean-Christophe Cassel Received 17 August 1999; accepted 26 November 1999 Acknowledgements: The authors would like to acknowledge the expert technical assistance of O. Bildstein and R. Paul. The research was supported by a grant from the MENRT/IFR 37–1999. NeuroReport: February 7, 2000 - Volume 11 - Issue 2 - p 347-350 Buy Abstract Young adult Long-Evans female rats were subjected to intracerebroventricular injections of 150 μg 5,7-dihydroxytryptamine (5,7-DHT), 2 μg 192 IgG-saporin, or a combination of both neurotoxins. All rats were tested for olfactory recognition (short-term memory) using a task based on spontaneous exploration of odor sources. Compared with animals undergoing sham operations, 5,7-DHT reduced the concentration of serotonin by 60–80% in the frontoparietal cortex, hippocampus, striatum and the olfactory bulbs. After 192 IgG-saporin treatment, acetylcholine concentrations were reduced by ∼40% in all these structures, except the striatum. Neither lesion induced a significant deficit in olfactory recognition. These data suggest that combined lesions of cholinergic and serotonergic neurons in the rat brain do not alter olfactory perception or olfactory short-term memory. © 2000 Lippincott Williams & Wilkins, Inc.