COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGYERP development in the rat in the course of learning two-tone discrimination taskTakeuchi, Satoshi1,2,3; Jodo, Eiichi1; Suzuki, Yoshiaki1,2; Matsuki, Tomohiko2; Hoshino, Ken-Yo2; Niwa, Shin-Ichi2; Kayama, Yukihiko1Author Information 1Departments of Physiology, Fukushima Medical University School of Medicine, Fukushima, Japan 2Departments of Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan 3Corresponding Author and Address: Satoshi Takeuchi, Departments of Physiology, Fukushima Medical University School of Medicine, Fukushima, Japan Received 2 November 1999; accepted 25 November 1999 NeuroReport: February 7, 2000 - Volume 11 - Issue 2 - p 333-336 Buy Abstract To clarify some neurophysiological aspects of learning, we investigated the relationship between the course of learning and development of ERP and investigated developmental processes of ERPs. Nine male Sprague-Dawley rats were trained for a two-tone discrimination task and rat P3 and N1 component were longitudinally recorded. Both rat P3 and N1 gradually increased with learning only for target tones. An improvement in the proportion of correct responses preceded the increase in ERPs, and the increase in P3 and N1 proceeded almost simultaneously. These findings suggest that multiple kinds of information processing were acquired with learning the two-tone discrimination task. ERP development could be utilized as an index of establishment of learning. © 2000 Lippincott Williams & Wilkins, Inc.