SOMATOSENSORY SYSTEMS, PAINDevelopmental dependency of Meissner corpuscles on trkB but not trkA or trkCIchikawa, Hiroyuki1,4; Matsuo, Saburo2; Silos-Santiago, Inmaculada3; Sugimoto, Tomosada1Author Information 1Second Department of Oral Anatomy and Biodental Research Center, Okayama University Dental School, 2-5-1 Shikata-cho, Okayama 700 2Department of Toxicology, School of Veterinary Medicine, Osaka Prefecture University, Sakai 599-8531, Japan 3Millennium Pharmac. Inc., Cambridge, MA 02139, USA 4Corresponding Author: Hiroyuki Ichikawa Received 21 October 1999; accepted 7 November 1999 NeuroReport: February 7, 2000 - Volume 11 - Issue 2 - p 259 Buy Abstract The distribution of S100-immunoreactive (ir) corpuscular endings was examined in the palate of wildtype and knockout mice for trkA, trkB or trkC. In wildtype mice, S100-ir corpuscular endings were abundant at the top of palatal rugae. The endings contained 2–4 parallel arrays of S100-ir neurites. The distribution of S100-ir nerve endings in trkA and trkC knockout mice was similar to that in wildtype mice; S100-ir corpuscular endings were abundant in palates of the mutant mice. In trkB knockout mice, the palate was devoid of corpuscular endings, An immunoelectron microscopic method indicated that S100-ir corpuscular endings were identical to Meissner corpuscles. The normal development of Meissner corpuscles is probably dependent on trkB but not trkA or trkC. © 2000 Lippincott Williams & Wilkins, Inc.