SOMATOSENSORY SYSTEMS, PAINContralateral treatment with xylocaine reduces nociceptive behaviour in mononeuropathic ratsBileviciute-Ljungar, Indre1,3; Lundeberg, Thomas1,2Author Information 1Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm 2Department of Surgery, Karolinska Hospital, 171 76 Stockholm, Sweden 3Corresponding Author: Indre Bileviciute-Ljungar Received 14 October 1999; accepted 9 November 1999 Acknowledgements: Supported by grants from Karolinska Institutet foundation, the foundation for the Acupuncture and Alternative Treatment Methods and the Wenner-Gren Center foundation. NeuroReport: February 7, 2000 - Volume 11 - Issue 2 - p 291-295 Buy Abstract The aim of the present study was to establish whether contralateral treatment with local anaesthetics reduces nociceptive behaviour in mononeuropathic rats. Contralateral treatment with xylocaine on day 6 and 11 following sciatic nerve ligation increased withdrawal latencies to thermal but not to mechanical stimulation for 3–4 days. Rats who received contralateral treatment with xylocaine on day 6 and 11 showed a reduced autotomy score during the following 6 weeks. To compare ipsilateral and contralateral effects another set of experiments was performed. Rats treated contralaterally on day 11 had a significantly lower autotomy score at week 4 and 6. Our results demonstrate that contralateral treatment with xylocaine reduces nociceptive behaviour in mononeuropathic rats for days or weeks. © 2000 Lippincott Williams & Wilkins, Inc.