Membrane and Cellular Biophysics and BiochemistryPhosphatidic acid is important to the translocation of Rab3A from the cytosol to phospholipid membranesJung, Yeon-Joo1; Lee, Tong-Ho1; Lee, Jae-Yong1; Kim, Jae-Hong2; Park, Jae-Bong1,3Author Information 1Department of Biochemistry, College of Medicine, Hallym University, Chun-Chon, Kang-Won Do, 200-702 2Department of Life Science, Kwang-Joo Institute of Science and Technology, Kwang-Joo, South Korea 3Corresponding Author: Jae-Bong Park ACKNOWLEDGEMENTS: The author wishes to acknowledge the financial support of the Korea Research Foundation made in the program year of 1997. Received 29 June 1999; accepted 19 July 1999 NeuroReport: September 9, 1999 - Volume 10 - Issue 13 - p 2859-2863 Buy Abstract RAB3A, a Ras-related GTP-binding protein, is found in a rat neuronal cytosol in the form of complex with RabGDI or located on the synaptic vesicles and it cycles between the cytosol and the membranes. However, the regulatory mechanism of the translocation of Rab3A has not been clearly understood. To understand the mechanism of the translocation of Rab3A from the cytosol to the membranes, we examined which membranenous phospholipid is required for the translocation of Rab3A. Phosphatidic acid (PA) was found to be required for the translocation of Rab3A to the membranes and GTPγS stimulated the translocation of Rab3A. © 1999 Lippincott Williams & Wilkins, Inc.