NeuroendocrinologyEffects of acute restraint stress on endogenous adrenomedullin levelsKhan, S1; Michaud, D1; Moody, T W.3; Anisman, H4; Merali, Z1,2,5 Author Information 1School of Psychology, 11 Marie-Curie, Vanier Hall Rm. 214, University of Ottawa, Ottawa, ON, K1N 6N5, Canada 2Department of Cellular and Molecular Medicine, 11 Marie-Curie, Vanier Hall Rm. 214, University of Ottawa, Ottawa, ON, K1N 6N5, Canada 3National Cancer Institute, Rockville, MD, USA 4Institute of Neuroscience, Carleton University, Ottawa, ON, Canada 5Corresponding Author and Address: Z. Merali, School of Psychology, 11 Marie-Curie, Vanier Hall Rm. 214, University of Ottawa, Ottawa, ON, K1N 6N5, Canada Received 16 June 1999; accepted 19 July 1999 NeuroReport: September 9, 1999 - Volume 10 - Issue 13 - p 2829-2833 Buy Abstract ADRENOMEDULLIN (ADM) is a 52 amino acid peptide, with a potent hypotensive/vasodilatory action. Levels of ADM are significantly elevated in patients with hypertension, and it has been postulated that such stressor-related increases may serve a regulatory or protective function. The current study assessed the effects of acute restraint stress on ADM levels in regions of the brain, plasma and peripheral tissue including heart, lung and the adrenal glands of rats. This stressor, known to stimulate sympathetic activity as well as the hypothalamic-pituitary adrenal (HPA) axis, produced a significant increase in ADM levels in the pituitary gland, plasma and adrenal glands, all of which are key components of the HPA axis. The results suggest a regulatory and/or protective role for ADM in countering HPA activation following a variety of physiological and psychological stressors. © 1999 Lippincott Williams & Wilkins, Inc.