NeuropharmacologyDopamine and DOPA cause release of iron from ferritin and lipid peroxidation of liposomesTanaka, Makoto1,3; Yoshida, Toshihiko1; Okamoto, Koichi1; Hirai, Shunsaku2Author Information 1Department of Neurology, Gunma University School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371–8511 2Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Huchu, Tokyo 183-0042, Japan. 3Corresponding Author: Makoto Tanaka ACKNOWLEDGEMENTS: We are indebted to Professor P. Jenner, University of London King's College, for his invaluable advice. Received 30 March 1999; accepted 24 April 1999 NeuroReport: June 23rd, 1999 - Volume 10 - Issue 9 - p 1883-1887 Buy Abstract WE investigated dopamine (DA)- and DOPA-related release of iron from ferritin, and lipid peroxidation of liposomes induced by the released iron. Iron release increased with increasing DA or DOPA concentrations. Effects of SOD and an oxygen-reduced environment indicated that superoxide was partly responsible for iron release. The released iron induced lipid peroxidation at relatively low concentrations of DA or DOPA, while at high concentrations, peroxidation was inhibited. These findings indicate that the risk of lipid peroxidation depends on the DA/iron or DOPA/iron ratio even if the iron concentration is low. Our findings suggest that DA-containing neurons are always at risk of oxidative damage. Furthermore, DOPA therapy may modify the nigral degeneration by reducing or accelerating ferritin iron-dependent lipid peroxidation. © 1999 Lippincott Williams & Wilkins, Inc.