Clinical NeuroscienceBrain hemorrhages after rt-PA treatment of embolic stroke in spontaneously hypertensive ratsBrinker, G1; Pillekamp, F1; Hossmann, K-A1,2Author Information 1Max-Planck-Institut für neurologische Forschung, Abteilung für experimentelle Neurologie, Gleueler Str. 50, D-50931 Cologne, Germany. 2Corresponding author: K.-A. Hossmann Received 12 April 1999; accepted 28 April 1999 NeuroReport: June 23rd, 1999 - Volume 10 - Issue 9 - p 1943-1946 Buy Abstract INTRACEREBRAL hemorrhage is a major complicating factor of thrombolytic therapy of stroke. To investigate the incidence of bleeding in animals with a diseased vascular system, thrombolysis was carried out in spontaneously hypertensive rats (SHR) after clot embolism of the right middle cerebral artery (MCA). Three hours after embolism SHR were treated with either recombinant tissue-plasminogen activator (rt-PA) or saline, and neurological deficits and intracerebral hemorrhages were evaluated after 3 days survival. Rt-PA-treated SHR exhibited a significantly higher incidence of hemorrhages than untreated rats but neurological deficits and survival rates showed a non-significant trend for improvement. This model offers the possibility of investigating the pathophysiology of post-thrombolytic complications in a clinically relevant small animal model. © 1999 Lippincott Williams & Wilkins, Inc.