Membrane Biophysics and BiochemistryBrain bioenergetics in murine models of scrapie using in vivo31P magnetic resonance spectroscopyChung, Yuen-Li1,4; Williams, Steve C.R.2; Hope, James3; Bell, Jimmy D.1Author Information 1Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road, London W12 0HS 2Department of Neurosciences, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF 3BBSRC Institute for Animal Health, Compton Laboratory, Compton, Berkshire RG20 7NN, UK. 4Corresponding Author: Yuen-Li Chung ACKNOWLEDGEMENTS: We would like to acknowledge the Medical Research Council for financial support and the University of London Intercollegiate Research Service (ULIRS) for access to the MR facilities at Queen Mary and Westfield College. We would also like to thank Irene McConnell (NPU) and her staff for their technical support. Received 3 March 1999; accepted 24 April 1999 NeuroReport: June 23rd, 1999 - Volume 10 - Issue 9 - p 1899-1901 Buy Abstract THE bioenergetic status of the brain in scrapie mouse models was investigated during the late, clinical phase of the disease, by in vivo phosphorus magnetic resonance spectroscopy (MRS). The only significant change observed in the scrapie-infected mice compared with controls was an increase in intracellular brain pH (7.20 ± 0.06 vs 7.10 ± 0.05). No other changes in energetic metabolism were observed in the infected mice beside a trend in the decrease of phosphomonoester (PME) level, possibly associated with an alteration in glycolytic intermediates. This study showed that even in the presence of severe cellular vacuolation and microglia infiltrate, cerebral bioenergetic is maintained. © 1999 Lippincott Williams & Wilkins, Inc.