Motivation, Emotion, Feeding, DrinkingEmotional impairment after right orbitofrontal lesion in a patient without cognitive deficitsAngrilli, Alessandro1,3; Palomba, Daniela1; Cantagallo, Anna2; Maietti, Alessandra2; Stegagno, Luciano1Author Information 1Dipartimento di Psicologia Generale, University of Padova, Via Venezia 8, 35131 Padova, Italy 2Unità Operativa di Medicina Riabilitativa, Ospedale di Ferrara, Via Boschetto 20, 44100 Ferrara, Italy 3Corresponding Author: Alessandro Angrilli Received 23 March 1999; accepted 13 April 1999 NeuroReport: June 3rd, 1999 - Volume 10 - Issue 8 - p 1741-1746 Buy Abstract THE present study describes a patient, M.L., with right orbitofrontal lesion, who showed no impairment on main neuropsychological tests, including those measuring frontal functions. Nevertheless, he had deeply affected emotional responses. In line with Damasio's work, the patient had lower skin conductance during the projection of a standardized set of emotional slides. Furthermore, he showed altered facial expressions to unpleasant emotions, displaying low corrugator supercilii electromyographical activity associated with reduced recall of unpleasant stimuli. During a task focusing on imagery of emotional situations, M.L.'s heart rate and skin conductance responses were affected during both pleasant and unpleasant conditions. Facial expressions to unpleasant imagery scripts were also impaired. Thus, the orbitofrontal cortex proved to play a critical role in retrieval of psychophysiological emotional patterns, particularly to unpleasant material. These results provide the first evidence that orbitofrontal lesions are associated with emotional impairment at several psychophysiological levels. © 1999 Lippincott Williams & Wilkins, Inc.