Learning and MemoryRetrosplenial cortex inactivation selectively impairs navigation in darknessCooper, Brenton G.1; Mizumori, Sheri J. Y.1,2Author Information 11530 East 390 South Rm. 502, Department of Psychology, University of Utah, Salt Lake City, UT 84112, USA 2Corresponding Author: Sheri J. Y. Mizumori ACKNOWLEDGEMENTS: This work was supported by a predoctoral fellowship MH11998 awarded to B.G.C. and NSF BNS-9514880 and NIH MH58755 grants to S.J.Y.M. We would like to thank James Canfield for his invaluable technical assistance on a variety of aspects of this project. Received 2 December 1998; accepted 4 January 1999 NeuroReport: February 25th, 1999 - Volume 10 - Issue 3 - p 625-630 Buy Abstract THERE is an emerging consensus that retrosplenial and posterior parietal cortex importantly contribute to navigation. Several theories of navigation have argued that these cortical areas, particularly retrosplenial cortex, are involved in path integration. In an effort to characterize the role of retrosplenial cortex in active navigation, the effects of temporary inactivation of retrosplenial cortex on spatial memory performance were evaluated in light and dark testing conditions. Inactivation of retrosplenial cortex selectively resulted in behavioral impairments when animals were tested in darkness. These data support the hypothesis that retrosplenial cortex contributes to navigation in darkness, perhaps by providing mnemonic associations of the visual and nonvisual environment that can be used to correct for cumulative errors that occur during path integration. © 1999 Lippincott Williams & Wilkins, Inc.