Brain imagingCortical tuning a function of anticipated stimulus intensityBäcker, Marcus1; Knecht, Stefan1,2; Deppe, Michael1; Lohmann, Hubertus1; Ringelstein, E-Bernd1; Henningsen, Henning1 Author Information 1Department of Neurology, University of Münster, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany. 2Corresponding Author: Stefan Knecht ACKNOWLEDGEMENTS: The authors would like to thank Professor Niels Birbaumer for his helpful comments on an earlier draft of this article. They also gratefully acknowledge Jörg Opterbeck, Rainer Merz, Manfred Sand, Marco Scherb and Jens Sommer for their skillful technical support. This work was supported by the Bennigsen–Foerder-Preis of Nordrhein-Westfalen (IVA 6-400 302 97), the Innovative Medizinische Forschung (KN 1-1/98-01) and the Deutsche Forschungsgemeinschaft (Kn 285/4–1) Received 30 September 1998; accepted 18 November 1998 NeuroReport: February 5, 1999 - Volume 10 - Issue 2 - p 293-296 Buy Abstract We investigated the activation of the brain during anticipation of tactile stimuli by continuous cerebral blood flow velocity (CBFV) monitoring with bilateral transcranial Doppler sonography. A forced choice paradigm was performed where a first group of subjects (n = 16) was expecting suprathreshold and a second group (n = 19) was anticipating threshold tactile stimuli to the index finger after a cueing tone. During the anticipation of suprathreshold stimuli the CBFV always exhibited a significantly stronger increase in the right hemisphere than in the left, even when stimuli were anticipated at the right index finger. Conversely when stimuli at perception threshold were expected, the respective contralateral hemisphere showed a significantly stronger perfusion increase. These data show that preparatory activation of the brain during stimulus anticipation is dependant on the expected stimulus intensity. © 1999 Lippincott Williams & Wilkins, Inc.