Motivation, emotion, feeding, drinking, sexual behaviourCentral administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in miceDantzer, Robert1,3; Gheusi, Gilles1; Johnson, Rodney W.2; Kelley, Keith W.2 Author Information 1Laboratory of Integrative Neurobiology, INRAINSERM U 394, Rue Camille Saint-Saens, 33077 Bordeaux Cedex, France 2Department of Animal Sciences, University of Illinois at Urbana, IL, USA. 3Corresponding Author: Robert Dantzer ACKNOWLEDGEMENTS: This work was supported by INRA, INSERM, the European Community (BIOMED 2, Cybrainet, CT 97-2492) and NIMH (MH 51569 to K.W.K.). Received 3 November 1998; accepted 18 November 1998 NeuroReport: February 5, 1999 - Volume 10 - Issue 2 - p 289-292 Buy Abstract To assess the possible modulatory effects of insulin-like growth factor-1 (IGF-1) on the brain effects of proin-flammatory cytokines, male CD-1 mice were injected into the lateral ventricle of the brain with a behaviorally depressing dose (100 ng) of the cytokine inducer lipopolysaccharide (LPS) and their response to various doses of IGF-1 (0, 100 and 1000 ng) was measured during behavioral tests carried before and at various time intervals after treatment. LPS induced a profound behavioral depression that was abrogated by the higher dose of IGF-1 tested. Since the behavioral effects of LPS are mediated by the local synthesis and results of proinflammatory cytokines, these results indicate that IGF-1 interferes with the production and/or action of proinflammatory cytokines in the brain. © 1999 Lippincott Williams & Wilkins, Inc.