Brain imagingStimulus inversion and the responses of face and object-sensitive cortical areasAguirre, Geoffrey Karl1,2; Singh, Rajiv1; D'Esposito, Mark1Author Information 1Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104–4283, USA 2Corresponding Author: Geoffrey Karl Aguirre ACKNOWLEDGEMENTS: This work was supported by grants from the National Institutes of Health (NS01762 and AG13483) and the Charles A. Dana Foundation and the American Federation for Aging Research. Received 16 September 1998; accepted 8 November 1998 NeuroReport: January 18th, 1999 - Volume 10 - Issue 1 - p 189-194 Buy Abstract BEHAVIORAL and neuropsychological studies suggest that upright and inverted face stimuli are processed by computationally and anatomically distinct systems. Specifically, inverted faces seem to be addressed by general object perception systems, avoiding face-specific processes. We tested this model by examining the fMRI signal response of a functionally defined fusiform face area and bilateral object-responsive cortical areas during the perception of upright and inverted stimuli (faces and cars). While inversion of face stimuli had no effect upon the magnitude of responses in the fusiform face area, inverted faces evoked greater neural responses compared to upright faces within object regions. This finding supports the assertion that object areas are involved to a greater degree in the perception of inverted vs upright faces. © 1999 Lippincott Williams & Wilkins, Inc.