Somatosensory Systems, PainRepresentation of nociceptive stimuli in primary sensory cortexBerman, Howard H.1,2; Kim, Karl H.S.1,3; Talati, Ardesheer1,2; Hirsch, Joy1,3,4Author Information 1Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA 2Department of Pharmacology, Cornell University Medical College, 1300 York Avenue, NY 10021, USA 3Department of Neuroscience, Cornell University Medical College, 1300 York Avenue, NY 10021, USA 4Corresponding Author: Joy Hirsch ACKNOWLEDGEMENTS: We are grateful to our colleagues Dr Norman Relkin, Dr Maximillian Ruge, Ray Cappiello, Steve Chun, and Diana Rodriguez-Moreno for intellectual and technical contributions. Supported by the William T. Morris Foundation Fellowship, NIH MSTP grant GM07739, the Cornell/Rockefeller/ Sloan-Kettering Tri-Institutional M.D.-Ph.D. Program (KHSK); the Charles A. Dana Foundation, Johnson & Johnson Focused Giving Foundation, Cancer Center Support Grant NCI-P30-CA-08748 (JH). Received 23 September 1998; accepted 22 October 1998 NeuroReport: December 21st, 1998 - Volume 9 - Issue 18 - p 4179-4187 Buy Abstract USING fMRI, we observed cortical activity associated with nociceptive hot and cold sensations applied to hand and foot that are not spatially restricted to the corresponding regions of the primary somatosensory cortex (SI). Hot (55–57°C) and cold (0–2°C) tactile stimuli were applied separately to the right hand and foot of eight right-handed subjects. Although somatotopic mapping of hand and foot was observed as expected based on the Penfield homunculus, activations associated with hot during both hand and foot stimulation and subsequently, cold, activated regions unique to each thermal modality irrespective of the body part. This distributed system for thermal information is present at both nociceptive and more neutral thermal intensities (i.e. warm and cool sensations) indicating the presence of distributed sensory processing associated with thermal-related sensations in human primary sensorimotor cortex. © 1998 Lippincott Williams & Wilkins, Inc.