Molecular NeuroscienceRegulated expression of dual specificity protein phosphatases in rat brainBoschert, Ursula1,4; Dickinson, Robin2; Muda, Marco3; Camps, Montserrat1; Arkinstall, Steve1Author Information 1Serono Pharmaceutical Research Institute, Serono International S.A., CH-1228 Plan-les-Ouates, Geneva, Switzerland 2University of Oxford, Department of Anatomy, South Parks Road, Oxford OX1 3QX, UK. 3Present Address: Medical Science I, Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109-0606, USA 4Corresponding Author: Ursula Boschert ACKNOWLEDGEMENTS: This work has been supported by grants from Laboratoire L. Lafon, Maisons-Alfort, France and Italian MURST (60%). Received 9 September 1998; accepted 7 October 1998 NeuroReport: December 21st, 1998 - Volume 9 - Issue 18 - p 4081-4086 Buy Abstract ACTIVATED mitogen-activated protein (MAP) kinases play an essential role controlling many neuronal functions. Dual specificity protein phosphatases (DS-PTPs) elicit selective inactivation of MAP kinases and are under tight transcriptional control. We have studied expression of four DS-PTPs (MKP-1, MKP-X, MKP-3 and B23) in rat brain and examined changes during post-natal development and following kainic acid induced seizure activity. In normal adult brain these DS-PTPs exhibit a strikingly different expression pattern. Only MKP-1 was regulated during development with levels increased transiently (P15-P21) within the thalamus and somatosensory cortex. Following kainate treatment, MKP-1, MKP-3 and B23 all exhibit striking changes in expression within hippocampal subfields CA1-3 and dentate gyrus. Regulated transcription of DS-PTPs may play a critical role controlling MAP kinase dependent processes including synaptic remodeling and neuronal death. © 1998 Lippincott Williams & Wilkins, Inc.