Synaptic TransmissionLTP occludes the interaction between arachidonic acid and ACPD and NGF and ACPDKelly, Aine1; Lynch, Marina A.1,2Author Information 1Department of Physiology, Trinity College, Dublin 2, Ireland 2Corresponding Author: Marina A. Lynch ACKNOWLEDGEMENTS: A.K. is a Trinity Foundation Fellow. The financial support of Forbairt (Ireland) is gratefully acknowledged. Received 7 October 1998; accepted 21 October 1998 NeuroReport: December 21st, 1998 - Volume 9 - Issue 18 - p 4087-4091 Buy Abstract WE compared the interaction between the metabotropic glutamate receptor agonist ACPD and arachidonic acid with the interaction between ACPD and nerve growth factor (NGF) on presynaptic function in hippocampus. ACPD interacted with both NGF and arachidonic acid to increase KCl-stimulated endogenous glutamate release and calcium concentration in synaptosomes prepared from whole hippocampus and synaptosomes prepared from untetanized dentate gyrus. The data indicate that prior induction of long-term potentiation (LTP) in perforant path granule cells synapses occluded the interaction between ACPD and both NGF and arachidonic acid, suggesting that these agents may play a role in the generation of LTP in dentate gyrus. © 1998 Lippincott Williams & Wilkins, Inc.