Auditory and Vestibular Systems, Lateral LineFibroblast growth factor receptor expression in outer hair cells of rat cochleaPickles, James O.2,3; Harter, Catherine1; Rebillard, Guy1Author Information 1INSERM U254, CHU Hopital St-Charles, 34205 Montpellier cedex 5, France 2Vision, Touch and Hearing Research Centre, University of Queensland, 4072 Qld., Australia 3Corresponding Author: James O. Pickles ACKNOWLEDGEMENTS: The guidance of Victor Nurcombe in the selection of primer regions was much appreciated. Supported by INSERM, the Australia-France Foundation, and the Garnett Passe and Rodney Williams Memorial Foundation. Received 23 September 1998; accepted 30 September 1998 NeuroReport: December 21st, 1998 - Volume 9 - Issue 18 - p 4093-4095 Buy Abstract FIBROBLAST growth factors (FGFs) are critical for normal development of the organ of Corti, and may also protect hair cells from ototoxic damage. Four different fibroblast growth factors are known, three of which have different splice variants in the extracellular immunoglobin-like (Ig) III FGF-binding domain, giving different patterns of sensitivity to the different FGFs. Analysis of a cDNA library of rat outer hair cells by the polymerase chain reaction, using isoform specific primers, showed expression only of FGF receptor 3, splice variant IIIc. This allows us to predict the pattern of sensitivity to applied FGFs, which may be useful in targeting outer hair cells selectively during an FGF-based strategy for cochlear therapy. © 1998 Lippincott Williams & Wilkins, Inc.