NeurochemistryBlockade of subthalamic dopamine D1 receptors elicits akinesia in ratsHauber, Wolfgang1Author Information 1Department of Animal Physiology, University of Stuttgart, Pfaffenwaldring 57, D-70550 Stuttgart, Germany ACKNOWLEDGEMENTS: Supported by the Deutsche Forschungsgemeinschaft (Ha 2340/1-2). The excellent technical assistance of Sonja Schmidt is gratefully acknowledged. Received 9 September 1998; accepted 13 October 1998 NeuroReport: December 21st, 1998 - Volume 9 - Issue 18 - p 4115-4118 Buy Abstract THE role of dopamine in the subthalamic nucleus to control motor behaviour was investigated in rats using bilateral microinfusions of the dopamine D1 receptor antagonist SCH23390 and the dopamine D2 receptor antagonist S(-)-sulpiride. Selective blockade of subthalamic D1 receptors, but not of D2 receptors, produced catalepsy. These findings suggest that dopamine D1 receptors within the subthalmic nucleus play a prominent role in the regulation of motor functions. Furthermore, the data point to the possibility that a reduced dopaminergic tone at subthalamic dopamine D1 receptors might contribute to akinesia in Parkinson's disease. © 1998 Lippincott Williams & Wilkins, Inc.