Autonomic Nervous SystemAndrogen receptor immunoreactivity is present in primary sensory neurons of male ratsKeast, Janet R.1,2; Gleeson, Rebecca J.1Author Information 1Department of Physiology and Pharmacology, University of Queensland, St Lucia Qld 4072, Australia 2Corresponding Author: Janet R. Keast ACKNOWLEDGEMENTS: This study was supported by the National Health and Medical Research Council of Australia. We are grateful to Dr Gail Prins (University of Illinois) for the gift of AR antiserum and to Dr David Vaney (University of Queensland) for the gift of DAPI. Received 23 September 1998; accepted 5 October 1998 NeuroReport: December 21st, 1998 - Volume 9 - Issue 18 - p 4137-4140 Buy Abstract WE have examined the distribution of androgen receptor (AR) immunoreactivity in L6 and S1 dorsal root ganglia of male rats in order to determine whether the sensory component of reflex circuits is likely to be androgen-sensitive. Nuclear AR immunoreactivity was present in almost half of the neurons, but was decreased markedly by castration; after castration nuclear staining was absent and a few neurons showed dim cytoplasmic staining. Of the neurons possessing AR, half also contained calcitonin gene-related peptide (CGRP); in turn, > 80% of CGRP neurons contained AR. AR staining was present in both large and small CGRP neurons. This study shows that testosterone is likely to influence many sensory neurons and may therefore play an important role in modulating visceral and somatic reflexes. © 1998 Lippincott Williams & Wilkins, Inc.