Motivation, Emotion, Feeding, Drinking, Sexual BehaviourReward-quality dependent anticipation in rat nucleus accumbensMiyazaki, Katsuhiko1,2; Mogi, Eucaly1; Araki, Nobuyuki3; Matsumoto, Gen1,4Author Information 1Laboratory of Brain-operative expression, Brainway group, Brain Science Institute (BSI), RIKEN, Wako, Saitama 351-0198, Japan 2Department of Information Sciences and Electronics, University of Tsukuba, 1-1-1 Tennodai Tsukuba, Ibaraki 305-0005, Japan 3Fuji Xerox Co., Ltd., Ashigarakami, Kanagawa 259-0157, Japan 4Corresponding Author: Gen Matsumoto ACKNOWLEDGEMENTS: The authors are grateful to Drs M. Ichikawa and M. Shigematsu for their comments and suggestions, to Drs H. Yamada and T. Kobayashi for their technical assistance, and also to Dr Michael Miller for correction of the English version of the manuscript. Received 21 July 1998; accepted 16 September 1998 NeuroReport: December 1, 1998 - Volume 9 - Issue 17 - p 3943-3948 Buy Abstract SINGLE unit recording in rat nucleus accumbens (NAcc) was used to ascertain NAcc neuronal activity in mediating of reward including its anticipation. Of the 103 neurons investigated, 63% showed some response in connection with the task activity. Of these, 20 units responded during delivery of the primary reward (food and/or water) and five responded during the time period preceding reward if the reward was delayed (four to food, one to water). These result suggest that NAcc neurons responded not only to the delivery of primary reward and task inducing anticipation of reward, but also represent the difference of reward quality between food and water specifically. © 1998 Lippincott Williams & Wilkins, Inc.