Clinical NeuroscienceRapid actions of insulin on sensory nerve functionDelaney, Carol A.1,3; Murchie, Karen J.2; Westerman, Roderick A.1; de Courten, Maximilian P.1Author Information 1International Diabetes Institute, 260 Kooyong Rd, Caulfield, Vic, 3162 2Department of Physiology, Monash University, Clayton, Vic, 3165, Australia 3Corresponding Author: Carol A. Delaney Website publication 12 August 1998 ACKNOWLEDGEMENTS: This work was supported by a Fellowship Award to Carol Delaney from the Juvenile Diabetes Foundation International. Received 26 April 1998; accepted 24 June 1998 NeuroReport: August 24, 1998 - Volume 9 - Issue 12 - p 2775-2779 Buy Abstract THE acute action of insulin on neurogenic flare was investigated using iontophoresis. Twenty-five patients with insulin-dependent diabetes mellitus (IDDM) and 25 age- and gender-matched controls were studied. Axon reflex vasodilatation was evoked by transdermal iontophoresis of acetylcholine (ACh) before and after skin treatment by the iontophoresis of insulin and measured using laser Doppler velocimetry. Axon reflex responses were reduced in IDDM patients compared with controls (p < 0.001) but were restored after the iontophoresis of insulin. Insulin iontophoresis had no effect on the size of the axon reflex response in control subjects (p < 0.05). This study confirms the reduction of the ACh-induced flare in human patients with IDDM and has demonstrated relatively rapid effects of insulin on this cutaneous neurogenic response. © Lippincott-Raven Publishers.