Molecular NeuroscienceThe Brn-3c transcription factor contains a neuronal-specific activation domainSmith, Martin D1; Morris, Peter J1; Latchman, David S1,2Author Information 1Department of Molecular Pathology, The Windeyer Institute of Medical Sciences, University College London Medical School, The Windeyer Building, 46 Cleveland Street, London W1P 6DB, UK 2Corresponding Author: David S Latchman ACKNOWLEDGEMENTS: We are grateful to Bill Schlaepfer (neurofilament) and Michael Wilson (SNAP-25) for the kind gift of promoter constructs. This work was supported by the Medical Research Council. Received 11 November 1997; accepted 16 January 1998 NeuroReport: March 30th, 1998 - Volume 9 - Issue 5 - p 851-856 Buy Abstract Brn-3a, Brn-3b and Brn-3c are closely related POU family transcription factors which are expressed predominantly in neuronal cells. Previously Brn-3a has been shown to activate a number of gene promoters in cotransfections carried out in different cell types, while Brn-3b inhibits the basal activity of these promoters. We show here that Brn-3c activates the same promoters as Brn-3a but only in co-transfections into neuronal cells and not in other cell types. This effect is dependent upon an N-terminal region of Brn-3c which acts as a neuronal cell specific activation domain when linked to a heterologous DNA binding domain. To our knowledge this is the first report of an activation domain with apparently neuronal specific activity. © Lippincott-Raven Publishers.