Vision, CentralRepetitive optical stimulation elicits fast receptive field changes in mature visual cortexEysel, Ulf T.1,2; Eyding, Dirk1; Schweigart, Georg1Author Information 1Abteilung Neurophysiologie, Medizinische Fakultät, Ruhr-Universität Bochum, D-44780 Bochum, Germany 2Corresponding Author: Ulf T. Eysel ACKNOWLEDGEMENTS: We thank Yves Frégnac for valuable suggestions and David Ballantyne for reading the manuscript. The support of the Deutsche Forschungsgemeinschaft (Ey 8/23 and SFB 509/C4) is gratefully acknowledged. Received 4 December 1997; accepted 18 January 1998 NeuroReport: March 30th, 1998 - Volume 9 - Issue 5 - p 949-954 Buy Abstract FAST associative cellular plasticity of visual cortical cells has been shown in vitro with electrical stimulation as well as in vivo by pairing of natural stimuli with artificial depolarization. Here we experimentally changed receptive field properties of single cells in the mature cat visual cortex with purely natural associative stimulation in vivo. Single cortical cells expanded their receptive fields within minutes into unresponsive regions and changed their functional receptive field structure for hours after associative co-stimulation of active and primarily unresponsive regions. The effects are interpreted as strengthening of subthreshold synaptic inputs. Repetitive stimulation with the same visual pattern can modify single cell properties in vivo within minutes and may be related to preattentive fast perceptual learning. © Lippincott-Raven Publishers.