Regeneration and TransplantationRegeneration of axons from central neurons into microchips at the level of the spinal cordLundborg, Göran1,5; Drott, Johan2; Wallman, Lars2,3; Reimer, Martina4; Kanje, Martin4Author Information 1Department of Hand Surgery and Experimental Research, Malmö University Hospital, S-205 02 Malmö 2Departments of Electrical Measurement, Lund Institute of Technology, Box 118, S-221 00 Lund 3Departments of Solid State Physics, Lund Institute of Technology, Box 118, S-221 00 Lund 4Department of Animal Physiology, Lund University, S-221 00 Lund, Sweden 5Corresponding Author: Göran Lundborg ACKNOWLEDGEMENTS: This investigation was supported by the Swedish Medical Research Council (05188) and Natural Science Research Council. We thank Marie Adler-Maihofer and Lena Stenberg for expert technical assistance. Received 17 December 1997; accepted 18 January 1998 NeuroReport: March 30th, 1998 - Volume 9 - Issue 5 - p 861-864 Buy Abstract AXONS from central neurons can regenerate into the tissue matrix formed within a silicone tube capped with two pieces of peripheral nerve, one of which had been sutured to a lesion in the spinal cord. Such axons can grow through a transversely positioned microchip in the tube. These observations suggest that it is feasible to establish functional contact between external electronic equipment and regenerating central nervous axons making it possible to monitor and control their electrical activity. The findings open new perspectives for restoration of motor and sensory functions following spinal cord lesions. © Lippincott-Raven Publishers.