Regeneration and TransplantationDifferential macrophage responses following pre- and postganglionic axotomyMagnusson, Sofia1,2; Kanje, Martin1Author Information 1Department of Animal Physiology, Lund University, Helgonav. 3B, S-223 62 Lund, Sweden 2Corresponding Author: Sofia Magnusson ACKNOWLEDGEMENTS: The present study was supported by grant from the Swedish Natural Science Research Council, the Crafoord foundation, the Swedish Physiographical Society and the Royal Swedish Academy of Sciences. We thank Marie Adler-Maihofer for excellent technical assistance. Received 17 December 1997; accepted 16 January 1998 NeuroReport: March 30th, 1998 - Volume 9 - Issue 5 - p 841-846 Buy Abstract HERE we report that macrophages in the rat superior cervical ganglia (SCG) respond differently to pre- and postganglionic axotomy. Postganglionic axotomy results in a rapid activation of resident macrophages, as measured by inducible nitric oxide synthase (iNOS) immunoreactivity, and a massive invasion by macrophages. Following preganglionic lesion there was no such rapid activation and the macrophage invasion was of much lower magnitude. A subpopulation of the macrophages also expressed haem oxygenase-1 (HO-1). The results are compatible with a model in which macrophages or their products, including nitric oxide (NO) and carbon monoxide (CO) could be important for induction of early changes in the nerve cell body, like an altered neuropeptide synthesis, which has been shown to accompany the regenerative response in peripheral ganglia. © Lippincott-Raven Publishers.