Motivation, Emotion, Feeding, Drinking, Sexual BehaviourMetabotropic glutamate receptors are necessary for sensitization by amphetamineKim, Jeong-Hoon1; Vezina, Paul1,2 Author Information 1Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue, MC 3077, Chicago, IL 60637, USA 2Corresponding Author: Paul Vezina ACKNOWLEDGEMENTS: This research was supported by a grant to P.V. from The Brain Research Foundation. Website publication 3 February 1998 Received 21 October 1997; accepted 25 November 1997 NeuroReport: February 16, 1998 - Volume 9 - Issue 3 - p 403-406 Buy Abstract THE contribution of metabotropic glutamate receptors (mGluRs) in the ventral tegmental area (VTA) to the induction of locomotor sensitization by amphetamine (AMPH) was investigated. Rats pre-exposed to AMPH in the VTA showed significantly higher locomotor activity when subsequently tested with a systemic AMPH challenge than rats preexposed to VTA saline. Rats pre-exposed to AMPH but co-injected with the selective mGluR antagonist (RS)-α-methyl-4-carboxyphenylglycine [(RS)-MCPG] did not show this effect. These findings indicate that activation of mGluRs in the VTA is necessary for the induction of locomotor sensitization by AMPH and provide further support for the important role played by excitatory amino acids in this site in the development of sensitization to AMPH. © Lippincott-Raven Publishers.