Motivation, Emotion, Feeding, Drinking, Sexual Behaviourα-Helical CRF9-41 prevents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226 in ratsKask, Ants1,3; Rägo, Lembit1; Harro, Jaanus2Author Information 1Department of Pharmacology, University of Tartu, Ülikooli 18, EE2400 Tartu, Estonia 2Department of Public Health, University of Tartu, Ülikooli 18, EE2400 Tartu, Estonia 3Corresponding Author: Ants Kask Received 13 June 1997; accepted 21 August 1997 NeuroReport: November 10th, 1997 - Volume 8 - Issue 16 - p 3645-3647 Buy Abstract WE reported previously that the neuropeptide Y (NPY) Y1 receptor antagonist, N2-(diphenylacetyl)-N-[(4hydroxy-phenyl)methyl]-D-arginine amide (BIBP3226) has an anxiogenic-like effect in the elevated plus maze test in rats. In this study we investigated the effect of the corticotropin-releasing factor (CRF) receptor antagonist, α-helical-CRF9-41 (α-h-CRF) on this response. BIBP3226 (5 μg, i.c.v.) induced an anxiogenic-like effect, which was blocked by pretreatment with α-h-CRF at a concentration (1 μg, i.c.v.) which alone failed to affect the elevated plus maze performance. Thus, the anxiogenic effect of a selective Y1 receptor blocker was prevented by the blockade of CRF receptors, suggesting antagonistic effects of endogenous NPY and CRF in shaping the response to novelty. © Lippincott-Raven Publishers.