NeurochemistryNeurotrophin-like immunoreactivity in the human trigeminal ganglionQuartu, Marina1; Geic, Monica1; Fiacco, Marina Del1,2Author Information 1Dipartimento di Citomorfologia, Università di Cagliari, Via G.T. Porcell, 2, 09124 Cagliari, Italy 2Corresponding Author: Marina Del Fiacco Received 12 August 1997; accepted 30 August 1997 NeuroReport: November 10th, 1997 - Volume 8 - Issue 16 - p 3611-3617 Buy Abstract THE localization of the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3) was demonstrated immunohistochemically in discrete neuronal subsets of the human trigeminal ganglion at ages ranging from 23 weeks of gestation to adulthood. Neurotrophin-containing subpopulations partially overlapped with each other and with those immunoreactive for the relevant trk receptor. Glial elements could also be immunostained, labelled satellite cells being particularly abundant in NT-3 stained sections. These results suggest that the neurotrophins are of functional significance for the human trigeminal primary sensory neurones throughout life. Their localization in the ganglion cellular components supports their function as target-derived trophic factors and as molecules effective in autocrine/paracrine interactions. © Lippincott-Raven Publishers.