Neuropharmacology and NeurotoxicologyIn vivo neurotrophic effects of GDNF on axotomized retinal ganglion cellsKlöcker, Nikolaj1; Bräunling, Frank1; Isenmann, Stefan1; Bähr, Mathias1,2Author Information 1Department of Neurology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany 2Corresponding Author: Mathias Bähr Received 12 August 1997; accepted 28 August 1997 NeuroReport: November 10th, 1997 - Volume 8 - Issue 16 - p 3439-3442 Buy Abstract THE identification of neurotrophic factors ameliorating secondary neuronal death in the mammalian CNS has raised hopes for improved treatment strategies in neurodegenerative diseases, CNS trauma and ischemia. Glial cell-line derived neurotrophic factor (GDNF) has potent neuroprotective properties in both the CNS and PNS. We sought to investigate whether GDNF exerts survival promoting effects on axotomized retinal ganglion cells (RGCs) in the adult rat in vivo. Transection of the optic nerve induces delayed retrograde death of ∼85% of RGCs within 14 days. Intraocular GDNF rescued 21% of the RGCs which would otherwise have died after axotomy (34% of the normal control population), thereby extending the group of neuronal populations responsive to GDNF. © Lippincott-Raven Publishers.