Developmental NeuroscienceMarked suppression of cortical auditory evoked response shortly before the onset of REM sleepNiiyama, Yoshitsugu1,3; Sekine, Atsushi2; Fushimi, Masahito2; Hishikawa, Yasuo2Author Information 1Department of Neuropsychiatry, College of Allied Medical Science, 1-1-1 Hondo, Akita-city, Akita 010, Japan 2Department of Neuropsychiatry, School of Medicine, Akita University, 1-1-1 Hondo, Akita-city, Akita 010, Japan 3Corresponding Author: Yoshitsugu Niiyama Website publication 29 September 1997 Received 3 July 1997; accepted 8 August 1997 NeuroReport: October 20th, 1997 - Volume 8 - Issue 15 - p 3303-3308 Buy Abstract IN 10 of 12 subjects examined, the amplitude of N300, a component of the cortical auditory evoked potential, was evidently smaller in rapid eye movement (REM) sleep than in non-REM sleep. The start of the reduction associated with the onset of the first episode of REM sleep was examined in these 10 subjects. In five of these, a marked reduction of N300 amplitude occurred 0.5–2.5 min before the appearance of muscle atonia of REM sleep. In two subjects, a similarly marked reduction of the N300 amplitude occurred 0.5–1.0 min before the disappearance of sleep spindles or K-complexes. This suggests that a suppression of the synchronizing mechanism in the cerebrum sometimes occurs briefly prior to the occurrence of other physiological phenomena associated with REM sleep. © Lippincott-Raven Publishers.