NeuroimmunologyAlterations of GABAAβ2/3 immunoreactivity in the dentate gyrus after perforant pathway lesionMizukami, Katsuyoshi1,2; Ikonomovic, Milos D.1; Mishizin, Amanda1; Sheffield, Roxanne1; Grayson, Dennis R.1; Armstrong, David M.1,3Author Information 1Neuroscience Research Center, MPC Hahnemann School of Medicine, Allegheny-Campus, 320 East North Avenue, Pittsburgh, PA 15212, USA 2Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba-shi, Ibaraki 305, Japan 3Corresponding Author: David M. Armstrong ACKNOWLEDGEMENTS: This work was supported by NIH grant AG 08206 and a grant provided by the Allegheny Singer Research Institute, Pittsburgh, PA. Website publication 3 October 1997 Received 8 July 1997; accepted 5 August 1997 NeuroReport: October 20th, 1997 - Volume 8 - Issue 15 - p 3379-3383 Buy Erratum Abstract IMMUNOCYTOCHEMICAL techniques were employed to examine the changes in the GABA receptor subunits β2/3 within the dentate gyrus of the rat brain 1, 3, 7, 14, 30 and 90 days after a unilateral perforant pathway lesion. Three days post-lesion we observed a decrease in β2/3 immunolabeling in the inner molecular layer of the dentate gyrus followed by a comparable decrease in the outer molecular layer 7 days post-lesion. These decreases were transient; 30 and 90 days post-lesion, β2/3 immunolabeling appeared similar to controls in the inner portion of the molecular layer, while in the outer region the labeling was increased. In this latter region we also observed a dense band of AChE fibers. Following survival times of 3 days we observed a diffuse staining of the neuropil in the hilar region, and a dense amorphous accumulation of peroxidase reaction product in the polymorphic region. These responses were transient and by 14 days the hilar/polymorphic region appeared indistinguishable from controls. These data suggest a unique pattern of immunoabeling in the molecular and polymorphic region in response to perforant pathway lesion. A putative explanation for this response is discussed. Erratum The publisher would like to apologise to the authors for an error in the article referenced below . The third authors name should read: Mishizen NeuroReport. 15(2):387, February 9th, 2004. © Lippincott-Raven Publishers.