Neurophysiology, Basic and ClinicalVoltage-activated intracellular calcium transients in thalamic relay cells and interneuronsMunsch, Thomas1; Budde, Thomas1; Pape, Hans-Christian1,2 Author Information 1Institut für Physiologie, Medizinische Fakultät, Otto-von-Guericke Universität, Leipziger Str. 44, D-39120 Magdeburg, Germany 2Corresponding Author: Hans-Christian Pape ACKNOWLEDGEMENTS: This work was supported by the Deutsche Forschungsgemeinschaft (INK-15, TP A5). T.B. was a Helmholtz fellow. Received 11 April 1997; accepted 11 May 1997 NeuroReport: July 28, 1997 - Volume 8 - Issue 11 - p 2411-2418 Buy Abstract THE dynamics of intracellular calcium concentration ([Ca2+]i) following activation of low voltage-activated (LVA) and high voltage-activated (HVA) Ca2+ currents were studied in identified relay neurons and interneurons of the rat dorsal lateral geniculate nucleus (LGNd) in situ using Ca2+ imaging and patch-clamp techniques. In relay neurons, [Ca2+]i transients associated with the LVA Ca2+ current showed a fairly homogeneous somatodendritic distribution, whereas HVA transients significantly decreased to 65% of the somatic value at 60 μm dendritic distance. In interneurons, LVA transients significantly increased to 239% of the somatic value at 60 μm dendritic distance, whereas HVA transients were not significantly different in the soma and dendrites. These results indicate differences in [Ca2+]i dynamics, which may reflect a heterogeneous distribution of Ca2+ channels contributing to subcellular compartmentation in the two types of thalamic neurons. © Lippincott-Raven Publishers.