Genetics of Nervous System DiseaseDifferential expression of transcription factors in the accumbens of an animal model of ADHDPapa, Michele1; Sergeant, Joseph A.3; Sadile, Adolfo G.2,4Author Information 1Institute Human Anatomy, Second University of Naples (SUN), Constantinopoli 16, 80138 Napoli, Italy 2Laboratory of Neurophysiology of Behaviour and Neural Networks, Second University of Naples (SUN), Constantinopoli 16, 80138 Napoli, Italy 3Department of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands 4Corresponding Author: Adolfo G. Sadile ACKNOWLEDGEMENTS: Supported by EU Human Capital and Mobility contract ERBCHRXCT930303 between the University of Amsterdam and the Second University of Naples, and by Telethon-Italy (grant # E. 513). Received 3 February 1997; accepted 6 March 1997 NeuroReport: May 6, 1997 - Volume 8 - Issue 7 - p 1607-1612 Buy Abstract TRANSCRIPTION factors have been used as neuronal markers in the nucleus accumbens (ACB) of male juvenile spontaneously hypertensive rats (SHR), an animal model of attention-deficit hyperactivity disorder (ADHD), to trace putative neural substrates. In SHR, immunocytochemistry and PC-assisted image analysis showed lower expression of pan-FOS, c-FOS, ZIF/268 in the shell, and the c-FOS and ZIF/268 in the core, with an increased level of JUN-B in the core. The differential lower basal expression of transcription factors in the ACB of an animal model of ADHD implies a reduced number of modules and might represent a neural substrate of the attention deficits seen in SHR and children with ADHD at low motivational levels. © Lippincott-Raven Publishers.