Cognitive Neuroscience and NeuropsychologyAdenosine A2a receptors in the nucleus accumbens modulate prepulse inhibition of the startle responseHauber, Wolfgang1,3; Koch, Michael2Author Information 1Department of Animal Physiology, University of Stuttgart, Pfaffenwaldring 57, D-70550 Stuttgart 2Department of Animal Physiology, University of Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany 3Corresponding Author: Wolfgang Hauber ACKNOWLEDGEMENTS: Supported by the Deutsche Forschungsgemeinschaft (Ha 2340/1 and SFB 307/C2). The excellent technical assistance of Sonja Schmidt is gratefully acknowledged. Received 3 February 1997; accepted 22 February 1997 NeuroReport: April 14, 1997 - Volume 8 - Issue 6 - p 1515-1518 Buy Abstract PREPULSE inhibition (PPI) of the acoustic startle response (ASR) was disrupted by systemic administration of apomorphine (APO) (2 mg/kg, i.p.). Microinfusion of the selective adenosine A2a-receptor agonist CGS21680 (0.05 mg in 1.0 ml per side) into the nucleus accumbens (NAc), had no significant effect in animals with systemic vehicle pretreatment, but significantly reversed the disruption of PPI in rats pretreated with APO. Adenosine is, therefore, involved in the control of PPI through its actions on A2a receptors in the NAc. APO-induced disruption of PPI is considered to represent an animal model useful for screening both typical and atypical antipsychotic agents. The present results add further support to the view that A2a-receptor agonists may be potentially useful antipsychotic agents. © Lippincott-Raven Publishers.